If you can master this strategy, a frontal assault on the Baneblade will almost never work. Ogryns (tie up in melee) are probably the best since they are still partially effective against vehicles and superunits. Catachans (grenade launchers), heavy weapons teams (suppression, and can also repair) and Leman Russ' (rather expensive, but the cannon disrupts) can fill this in a limited role, but not all power melee can be suppressed. However, the Baneblade is too slow to outrun most squads. The most effective way to deal with this is having 2-3 guardsmen squads on the sides constantly repairing the Baneblade as it backs up. For many factions, standard strategy to combat a Baneblade is with a strong power-melee unit (Nobs, Assault Terminators, another melee superunit, upgraded hero), since the Baneblade has a certain minimum range for many of its weapons. Often, an IG army with a Baneblade can outshoot any other faction. The Baneblade is one of the only two ranged superunits, and is certainly the one with more firepower and range. Its doable, sure, but a huge pain in the ass to actually execute. You can largely forget about using both, due to how the hull is designed. Youre either using a Baneblade+variants, or a Shadowsword+variants.
Having it alone without even a squad of guardsmen is the number one way to lose a super heavy. If youre doing it because it was a badass unit in Dawn of War, prepare to be massively disappointed. Ensure that the Baneblade has at least some fire support to go with it.